NOSTRIN Antibody, Biotin conjugated

Code CSB-PA818236LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NOSTRIN Polyclonal antibody
Uniprot No.
Target Names
NOSTRIN
Alternative Names
BM247 antibody; BM247 homolog antibody; DaIP2 antibody; eNOS-trafficking inducer antibody; mDaIP2 antibody; MGC20702 antibody; Nitric oxide synthase traffic inducer antibody; Nitric oxide synthase trafficker antibody; NOSTN_HUMAN antibody; Nostrin antibody; RP23-431D4.2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Nostrin protein (1-322AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
Gene References into Functions
  1. The suggest that scores obtained with the worst nostril are the most efficient in detecting an olfactory disorder. PMID: 28981819
  2. NOSTRIN inhibited production of nitric oxide (NO) by suppressing the activation of endothelial nitric oxide synthase (eNOS). PMID: 27401251
  3. no significant difference in serum level associated with preeclampsia or intrauterine growth restriction PMID: 24588201
  4. This study showed that overexpression of NOSTRIN had a significant effect on eNOS activity in HUVECs and resulted in significant cellular damage. PMID: 23592143
  5. The expression of NOSTRIN is decreased, while the activity of eNOS and the level of NO2-/NO3- increased in the testis tissue of azoospermia patients. PMID: 21351530
  6. Results reveal an elegant mechanism of eNOS regulation by PECAM-1 through signal transducers and activators of transcription 3-mediated transcriptional control of NOSTRIN. PMID: 21183735
  7. NOSTRIN expression was increased in umbilical vessel of women with pre-eclampsia. PMID: 19399414
  8. NOSTRIN modulates nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. PMID: 12446846
  9. NOSTRIN may facilitate endocytosis of endothelial nitric oxide synthase by coordinating the function of dynamin and the actin nucleation promoting factor N-WASP. PMID: 16234328
  10. A ternary complex between NOSTRIN, caveolin-1, and eNOS mediates translocation of eNOS, with important implications for the activity and availability of eNOS in the cell. PMID: 16807357
  11. results suggest that nuclear NOSTRINbeta may negatively regulate transcription of the NOSTRIN gene PMID: 18980613

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Subcellular Location
[Isoform 1]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).; [Isoform 3]: Nucleus.
Tissue Specificity
Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).
Database Links

HGNC: 20203

OMIM: 607496

KEGG: hsa:115677

UniGene: Hs.189780

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